With the advent of an aging society, bone-related diseases have imposed a substantial burden on both the general population and healthcare systems, highlighting the urgency of finding new treatment methods. The occurrence and progression of such diseases are closely linked to inflammatory responses. Moxibustion, as a traditional external treatment in Traditional Chinese Medicine (TCM), is well-known for its significant anti-inflammatory and analgesic effects. Previous research indicates that moxibustion demonstrates remarkable therapeutic efficacy in treating bone-related diseases. Thus, this paper reviews the impact of moxibustion on inflammatory responses associated with bone-related conditions. The results show that the anti-inflammatory mechanism of moxibustion in treating bone-related diseases involves mediating pro-inflammatory factors, anti-inflammatory factors and related mediators, and regulating signaling pathways (NF-κB、JAK/STAT、MAPK、PD-1/PD-L1、AMPK /ULK1), hypothalamic-pituitary-adrenal axis, regulating the activation of immune cells, autophagy activity, etc. Despite these findings, the anti-inflammatory mechanisms underlying moxibustion treatment for bone-related diseases remain inadequately understood. Future research should focus on utilizing advanced technologies to gain a more comprehensive understanding of the anti-inflammatory mechanisms involved in moxibustion therapy. This approach aims to facilitate better clinical applications and contribute to safeguarding human bone health.