The incidence of autism is rising annually, and the repetitive stereotyped behaviors that characterize its core symptoms are varied and challenging to treat due to unclear pathogenesis. The striatum is an important brain region for behavioral research, with a unique mosaic structure, complex neural origin, and finely regulated developmental process, which is highly susceptible to genetic and environmental influences. Both clinical and basic studies have indicated that abnormal development of the striatal nuclei may contribute to the pathogenesis of these repetitive stereotyped behaviors in autism. Previous clinical imaging data have primarily revealed variations such as the general outline of the nuclei; however, they have been unable to detect the internal microstructure within these nuclei. By examining abnormalities in the spatiotemporal development of the striatum, we aim to advance our understanding of repetitive stereotyped behaviors associated with autism and provide guidance for future animal experiments and clinical research endeavors.