一氧化氮合酶在阿尔兹海默症发病机制中的作用
DOI:
作者:
作者单位:

1.南昌大学抚州医学院生理学教研室;2.南昌大学抚州医学院慢性病研究重点实验室;3.抚州市慢性病研究技术创新中心;4.南昌大学基础医学院病原生物学实验中心

作者简介:

通讯作者:

中图分类号:

基金项目:

国家自然科学基金项目(面上项目,重点项目,重大项目)


The rRole of nitric oxide synthase in the pathogenesis of Alzheimer"s disease
Author:
Affiliation:

1.Department of Physiology,Fuzhou Medical College of Nanchang University,Jiangxi,Fuzhou;2.Key Research Laboratory of Chronic Disease, Fuzhou Medical University, Jiangxi, Fuzhou;3.Technology Innovation Center of Chronic Disease Research in Fuzhou City, Fuzhou Science and Technology Bureau, Fuzhou;4.Department of Physiology, Fuzhou Medical College of Nanchang University;5.Key Research Laboratory of Chronic Disease, Fuzhou Medical University;6.Technology Innovation Center of Chronic Disease Research in Fuzhou City, Fuzhou Science and Technology Bureau;7.Experimental Center of Pathogen Biology, Basic College of Medicine

Fund Project:

The National Natural Science Foundation of China (General Program, Key Program, Major Research Plan)

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    一氧化氮合酶(Nitric oxide synthase,NOS)及其催化生成的一氧化氮(NO)参与学习和记忆发生机制?越来越多的证据表明NOS通过影响β淀粉样蛋白(β-amyloid protein,Aβ)沉积?神经炎症?氧化应激?小胶质细胞的异常激活?突触损伤?自噬?神经细胞线粒体功能异常及脑血流灌注不足或血管内皮细胞损伤等阿尔茨海默症(Alzheimer’s disease,AD)的病因,在AD的发生发展中发挥重要作用?本文总结了近年来NOS在AD发病机制中的作用进展,将为临床预防与治疗AD提供新靶点?

    Abstract:

    Nitric oxide synthase (NOS) and its produced nitric oxide (NO) involve in learning and memory functions. There is increasing evidence that NOS plays an important role in the pathogenesis of Alzheimer's disease (AD) by influencing β-amyloid protein (Aβ) deposition, neuroinflammation, oxidative stress, abnormal microglia activation , damaged synapse , autophagy, abnormal mitochondrial function of nerve cells, and cerebral hypoperfusion or vascular endothelial cell injury. This article summarizes the role of NOS in the pathogenesis of AD in recent years, which will provide new feasible targets for the prevention and treatment of AD.

    参考文献
    相似文献
    引证文献
引用本文
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:2024-12-21
  • 最后修改日期:2025-03-20
  • 录用日期:2025-06-23
  • 在线发布日期:
  • 出版日期: