母体肥胖通过调节心肌代谢导致子代心肌肥大的研究进展
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1.内蒙古医科大学基础医学院;2.呼和浩特市中医蒙医医院消化内科

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内蒙古自治区自然科学基金(2022LHMS03001);内蒙古自治区本级人才引进项目(2020);呼和浩特市卫生健康领域科技计划项目(呼卫健医疗-2023001)


Research progress on maternal obesity leading to offspring myocardial hypertrophy by regulating myocardial metabolism
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Affiliation:

1.School of Basic Medical Sciences,Inner Mongolia Medical University;2.Department of Gastroenterology,Hohhot Hospital of Traditional Chinese Medicine and Mongolian Medicine

Fund Project:

Natural Science Foundation of Inner Mongolia Autonomous Region (2022LHMS03001); Talent Introduction Project of Inner Mongolia Autonomous Region (2020); Science and Technology Plan Project in the Field of Health and Wellness of Hohhot City (Huhhot Health Medical - 2023001)

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    摘要:

    近年来,母体肥胖在子代心血管疾病发展中的作用引起了广泛的关注,不仅影响母亲健康,还可通过多种途径影响子代心血管系统发育,增加成年后患心脏病的风险。孕期高热量摄入导致孕妇肥胖,使胎儿暴露在宫内富营养环境中,促使心肌细胞适应性的调整脂肪酸、葡萄糖和酮体代谢等能源物质的摄取和消耗。近期研究表明母体肥胖可以影响子代心肌代谢使其发生重构,心脏中的ROS增加,从而持续激活mTOR和Hippo通路,诱导心肌细胞增殖和肥大。另一方面Hippo通路还可以作为心肌肥大的潜在治疗靶点。本综述的主要目的是概述母体肥胖如何通过影响胎儿期的心肌细胞代谢,进而促进子代心肌肥大的发展,探讨表观遗传学机制在调控心肌肥大的关键作用,同时讨论母体肥胖对后代心肌健康的远期效应。此外,本综述建议未来研究应放在深化代谢记忆,跨代遗传效应和早期生命干预策略方面。

    Abstract:

    The pathogenesis of cardiovascular diseases of individuals is largely resulted from their maternal obesity (MO), which attracts much attention in recent years. In addition to jeopardizing maternal health, MO increases the risks of offspring heart attack via affecting development of cardiovascular system. The prenatal high-calorie intake leads to the fetal overnutrition that alters the use of fatty acids, glucose, and ketones in cardiomyocytes. Studies indicated that the influences of MO on offspring include the cardiomyocyte metabolism and remodeling, as well as heart ROS increase, which therefore stimulates mTOR and Hippo pathways to induce cardiomyocyte proliferation and hypertrophy. Interestingly, Hippo pathway could potentially be a therapeutic target of cardiomyocyte hypertrophy. This review aims to disclose the role of MO in regulating the fetal cardiomyocyte metabolism, the offspring cardiomyocyte hypertrophy and the epigenetic mechanism thereof. Furthermore, the long-term effects of MO on offspring cardiomyocyte health is discussed. It is suggested that the metabolic memory, the cross-generational genetic effects, and the early-life intervention be laid great emphasis for the future researches.

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  • 收稿日期:2025-01-07
  • 最后修改日期:2025-04-18
  • 录用日期:2025-06-26
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