Parkinson's disease (PD) is a common progressive neurodegenerative disease mainly in the motor system. In recent years, some genetic factors and cellular mechanisms of Parkinson's disease have been discovered, and emerging evidence suggests that epigenetic modifications and phenomena play a very important role in the prevention and treatment of Parkinson's disease. Epigenetic modification mediates genetic and environmental interactions mainly through the complex interaction of DNA methylation, histone modification and non-coding RNA, thereby affecting different expressions in the absence of changes in DNA sequence. In this review, we introduce the epigenetic modification mechanisms involved in the pathogenesis of Parkinson's disease. Recent studies have found that traditional Chinese medicine can participate in the regulation of abnormal epigenetic modification in the treatment of Parkinson's disease, and traditional Chinese medicine has a unique advantage in the treatment of Parkinson's disease, with a multi-level and multi-target overall regulatory effect. Scholars at home and abroad have studied the intervention of Parkinson's disease by traditional Chinese medicine monomers, traditional Chinese medicine compound prescriptions, and appropriate traditional Chinese medicine techniques, which confirms that traditional Chinese medicine has a good prospect in improving symptoms and research for Parkinson's disease. This article reviews the mechanisms of epigenetics in Parkinson's disease, explores the role of traditional Chinese medicine in it, and aims to provide new ideas for the clinical treatment and drug development of Parkinson's disease through epigenetic intervention.