Alzheimer "s disease (AD) is a typical progressive neurodegenerative disease,mainly manifested as severe cognitive dysfunction,involving memory, thinking and emotion.Kynurenine pathway (KP) is one of the main metabolic pathways of tryptophan,which is divided into neurotoxicity branch and neuroprotective branch.In recent years,more and more evidence has shown that KP is involved in the pathogenesis of AD.In this paper,the effect of KP on the pathogenesis of AD was analyzed by referring to the relevant literature on KP intervention in AD in PubMed database,which provided an important reference for KP as a target for AD drug development.