星形胶质细胞-神经元能量代谢偶联失衡在AD发生发展中的作用及中药干预研究进展
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作者单位:

1.河南中医药大学;2.成都医学院

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基金项目:

中国博士后科学基金,国家自然科学基金项目(面上项目,重点项目,重大项目)


The Role of Astrocyte-Neuron Energy Metabolism Coupling Imbalance in the Pathogenesis and Progression of Alzheimer's Disease and Research Progress on Traditional Chinese Medicine Interventions
Author:
Affiliation:

1.Henan University of Chinese Medicine;2.Chengdu Medical College

Fund Project:

China Postdoctoral Science Foundation,The National Natural Science Foundation of China (General Program, Key Program, Major Research Plan)

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    摘要:

    能量代谢紊乱是导致认知功能障碍的重要原因,星形胶质细胞作为神经元能量来源的供给者,二者在多种供能机制的协调下,在脑内进行丰富的能量代谢活动,以维持正常认知的发生。星形胶质细胞-神经元的能量代谢偶联失衡引起脑内神经元功能异常,进而促进阿尔茨海默病(Alzheimer"s disease,AD)的发生发展。从能量代谢角度出发,探寻与AD相关的病理机制和治疗靶点,对该疾病今后的治疗和干预尤为重要。中药具有多成分、多靶点的作用特点,已有报道显示部分中药可以调节脑能量代谢,因此,调节脑能量代谢可能是中药改善AD的重要途径。本文就星形胶质细胞-神经元能量代谢偶联失衡在AD发生发展中的作用及中药的干预研究进展进行综述。

    Abstract:

    Disorders in energy metabolism are a critical factor contributing to cognitive dysfunction. Astrocytes, as key suppliers of energy substrates to neurons, engage in extensive energy metabolism activities in the brain under the coordination of various energy supply mechanisms to sustain normal cognitive function. Imbalances in astrocyte-neuron energy metabolism coupling lead to abnormal neuronal activity, thereby driving the pathogenesis and progression of Alzheimer"s disease (AD). Investigating the pathological mechanisms and therapeutic targets associated with AD from the perspective of energy metabolism is essential for future disease treatment and intervention. Traditional Chinese medicine (TCM), characterized by its multi-component and multi-target effects, has shown potential in regulating cerebral energy metabolism, suggesting that modulating brain energy metabolism may represent a significant pathway for TCM in ameliorating AD. This review systematically elucidates the mechanistic role of astrocyte-neuron bioenergetic coupling dysregulation in the pathogenesis and progression of AD, and critically evaluates recent advancements in therapeutic interventions mediated by TCM.

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  • 收稿日期:2025-02-24
  • 最后修改日期:2025-04-03
  • 录用日期:2025-07-23
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