Objective: To investigate the therapeutic effect of Qingxin Yunpi Formula on food allergy (FA) - related atopic dermatitis (AD) model mice induced by 2,4-dinitrochlorobenzene (DNCB)+ovalbumin (OVA). Method: BALB/c male mice were randomly divided into blank group, AD group, ADFA model group, Qingxin Yunpi Formula medium dose group, Qingxin Yunpi Formula high-dose group, and prednisone group, with 10 mice in each group. Except for the blank group and AD group, all other groups were treated with DNCB on the back and OVA was injected intraperitoneally to establish an ADFA model. The AD group was treated with DNCB on the back. At the end of modeling, the condition of skin lesions, dermatitis scores, and scratching behavior were recorded. Skin pathology, epidermal thickness, and mast cell infiltration were observed. Enzyme linked immunosorbent assay (ELISA) was used to detect serum OVA specific IgE (OVA sIgE) levels and serum cytokine levels of interleukin-4 (IL), IL-5, and interferon (IFN) - γ. Immunohistochemistry (HIC) was used to detect the expression of IL-4, IL-5, and IFN - γ proteins in the skin lesion tissue. Result: Compared with the blank group and AD group mice, the ADFA model group mice had severe back skin lesions, increased dermatitis score and scratching frequency, thickened back epidermis and spinous layer, and more inflammatory cell infiltration in the dermis layer. The serum OVA sIgE level of mice increased, and the serum cytokine IL-4, IL-5, IFN - γ levels increased. The expression of IL-4, IL-5, IFN - γ protein in the skin lesion tissue also increased; Compared with the ADFA model group, the mice in each treatment group showed improvement in back skin lesions, dermatitis scores