Immunogenic cell death (ICD) is a special cell death mode that can activate the immune system, especially in the treatment of cancer. ICD can enhance the recognition and attack of the immune system on tumors by releasing a series of damage associated molecular patterns (DAMPs), so as to achieve the effect of killing tumors. Oncolytic virus (OV) is a kind of virus that can selectively infect and kill tumor cells while preserving normal cells from damage. OVs, as type II ICD inducers, induce ICD in tumor cells by targeting the endoplasmic reticulum. Based on the characteristics of ICD, this review further elaborated the mechanism of ICD induced by OVs and the latest clinical progress, providing some ideas and references for the future treatment of tumors.