肌少症细胞模型研究进展
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作者单位:

1.河南中医药大学中医药科学院;2.河南中医药大学中医学院仲景学院 郑州

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基金项目:

国家自然科学基金项目(面上项目,重点项目,重大项目)


Research Progress on Cell Models of Sarcopenia
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Affiliation:

1.Academy of Chinese Medica Sciences,Henan University of Chinese Medicine;2.Traditional Chinese Medicine Zhong Jing School,Henan University of Chinese Medicine

Fund Project:

The National Natural Science Foundation of China (General Program, Key Program, Major Research Plan)

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    摘要:

    肌少症是骨骼肌质量及功能加速丧失的全身性疾病,导致跌倒、骨折等不良结局发生率增高。肌少症分为原发性与继发性两类,其中原发性肌少症与增龄密切相关,严重威胁老年人的健康生活。肌少症发病隐匿,在临床治疗中易被忽视。其发病机制复杂,涉及多个系统功能变化和病理改变,给相关研究带来诸多挑战。细胞模型能在可控条件下有效模拟疾病病理变化过程,有助于探究肌少症的病因及影响因素,为深入研究肌少症的作用机制提供重要途径。然而,在当前肌少症研究领域尚未有标准化的细胞模型,现阶段常用细胞模型包括蛋白质代谢干预、氧化应激、炎症反应干预等模型。本文对常用骨骼肌细胞类型及造模方法进行系统梳理及探讨,为肌少症后续实验研究进一步模拟肌少症的病理进程提供坚实基础和重要的方法学参考。

    Abstract:

    Sarcopenia is a systemic disease characterized by accelerated loss of skeletal muscle mass and function, leading to an increased incidence of adverse outcomes such as falls and fractures. Sarcopenia is classified into primary and secondary types, with primary sarcopenia being closely related to aging and posing a serious threat to the healthy life of the elderly. Sarcopenia has an insidious onset and is often overlooked in clinical treatment. Its pathogenesis is complex, involving functional changes and pathological alterations in multiple systems, presenting significant challenges for related research. Cell models can effectively simulate the pathological changes of diseases under controllable conditions, facilitating the exploration of the etiology and influencing factors of sarcopenia and providing an important approach for in-depth study of its mechanism of action. However, there is currently no standardized cell model in the field of sarcopenia research. Commonly used cell models at present include those involving protein metabolism intervention, oxidative stress, and inflammatory response intervention. This article systematically reviews and discusses the commonly used skeletal muscle cell types and modeling methods, providing a solid foundation and important methodological reference for further simulation of the pathological process of sarcopenia in subsequent experimental studies.

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  • 收稿日期:2025-03-25
  • 最后修改日期:2025-04-29
  • 录用日期:2025-07-23
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