Myocardial infarction (MI) is a critical and highly fatal cardiovascular disease that seriously threatens patients "lives. More possible new targets need to be explored to protect heart function and prevent the progression of heart failure. The Triggering Receptor Expressed Myeloid Cell (TREM) is an activating transmembrane receptor belonging to the immunoglobulin superfamily. TREM-1 and TREM-2 are the most important family members, and are mostly expressed on the surface of myeloid cells. The two have similar transmembrane glycostructural proteins, but they play different roles in regulating inflammatory responses. Myeloid cell-triggered receptors play an important role in the inflammatory response, myocardial remodeling, and myocardial cell regeneration after myocardial infarction. This article introduces the biological functions, expression forms, and ligand combinations of TREM-1 and TREM-2, and discusses the role of their mediated signaling pathways in myocardial infarction to find potential new targets for the treatment of myocardial infarction diseases.