The global incidence rate of autism spectrum disorder (ASD) shows a significant upward trend. Its pathological mechanism analysis and intervention strategy development have become a major challenge in the field of neurodevelopmental disorders. Exercise intervention can significantly alleviate social disorders, cognitive deficits, and stereotyped behaviors in ASD patients, but its neurobiological mechanisms still need to be systematically elucidated. Based on the pivotal role of the striatum in the cortical basal ganglia loop and its close association with ASD behavioral phenotype and functional abnormalities, this study focuses on the key mediating role of striatal functional remodeling in exercise intervention. Through the integration of animal experiments and clinical research evidence, it has been found that the striatum plays a potential role in improving autism behavior through exercise, including strengthening the morphological structure of striatal brain regions, improving the expression of striatal neurotrophic factors, regulating the transmission of dopamine signals in striatal brain regions, enhancing the transmission of cortical striatal glutamatergic signals, and other possible mechanisms by which exercise improves striatal function. By exploring the potential role of the striatum in improving autism behavior through exercise, this multi-scale analysis framework aims to elucidate the potential role of "motor striatal functional remodeling ASD behavior improvement" and provide new ideas for exercise in improving autism behavior.