Endometriosis (EMs) is a common estrogen-dependent disease in women of childbearing age, which often leads to chronic pelvic pain, infertility, ovarian cancer and other serious complications, jeopardizing the health of women.The pathogenesis of EMs is complex and involves the alteration of multiple signaling pathways mediated by hormones, immunity, genetics and environment and their interactions.Wnt/β-catenin signaling is involved in the regulation of embryonic development and tissue homeostasis, and recent studies have revealed that it may be involved in the pathogenesis of EMs in multiple ways. The Wnt/β-catenin signaling pathway is involved in the regulation of embryonic development and tissue homeostasis, and has been found to be involved in the pathogenesis of EMs through multiple pathways in recent years. Based on this, this paper systematically describes the biological characteristics of the Wnt/β-catenin signaling pathway, summarizes the main mechanisms and signaling pathways involved in the pathogenesis of EMs, as well as the current status of research on the regulation of this signaling pathway by traditional Chinese medicine for the intervention of EMs. We aim to clarify how the Wnt/β-catenin signaling pathway affects the development of EMs, and in the future, we should focus on exploring whether it can become one of the indicators for clinical prediction and early diagnosis of EMs, so as to provide theoretical support for the early diagnosis of EMs and the research and development of targeted drugs.