Methamphetamine use disorder (MUD) is a refractory disorder worldwide with limited treatment options. Studies have found that neuropeptides may be a new target for the treatment of MUD. Studying the regulatory mechanism of neuropeptides on MUD may provide new options for the treatment of MUD. However, there are many kinds of neuropeptides, the mechanism of action is complex, and the clinical drug reference is limited. This review focuses on orexin (OX), oxytocin (OT), vasopressin (VP), neurotensin (NT), neuropeptide S (NPS), neuropeptide Y (NPY), somatostatin (SST), pituitary adenylate cyclase-activating peptide (PACAP), vasoactive intestinal peptide (VIP), glucagon-like peptide-1 (GLP-1) and so on The regulatory role and mechanism of the peptide in MUD. This article provides new ideas for the treatment of MUD and promotes its application in the treatment of MUD.