Sjogren's syndrome (SS) is a chronic autoimmune disease with complex pathogenesis. In addition to lymphocyte infiltration and inflammatory damage of the glands，it often involves multiple systems，but the treatment options are limited. Studies have found that mitochondrial quality control dysfunction is closely related to the inflammation of autoimmune diseases. This article aims to study the correlation between mitochondrial quality control dysfunction and glandular damage in SS，with a view to broadening the horizons for the treatment of SS.