Deep vein thrombosis (DVT) is the third most common cardiovascular disease in the world.Traditional anticoagulation therapy is limited. The pathophysiology of DVT usually focuses on Virchow triad, but it cannot explain many clinical problems, and the interaction between metabolic reprogramming and inflammation and coagulation may open up new perspectives for its theory. To explore the role of metabolic microenvironment in thrombosis and oxidative stress in metabolic reprogramming and thrombosis, analyze the feedback loop between metabolic reprogramming and inflammatory coagulation, summarize the therapeutic strategies of metabolic regulation intervention in DVT, including glucose metabolism, lipid metabolism intervention and antioxidant therapy, and point out the challenges faced by the therapeutic strategy level, providing a new way for the prevention and treatment of DVT.