Macrophages, as intrinsic immune cells, are an important component of innate immunity and play an important role in immunity against Mycobacterium tuberculosis (Mtb) infection.After infecting the organism, Mtb mainly parasitizes macrophages, where it can survive and multiply, and induce different modes of cell death, including apoptosis, autophagy, pyroptosis, iron death, and necrotic apoptosis.Different modes of cell death play different roles in the process of Mtb infection. This paper provides a review of the different ways of macrophage death pathways and their roles after Mtb infection, with the aim of deepening the understanding of the potential impacts on host immunity during Mtb infection, and providing references for further research on the pathogenic mechanism of Mtb and the strategy of anti-tuberculosis treatment.