Aim: This study aimed to evaluate the feasibility of establishing a hypertensive rat model induced by deoxycorticosterone acetate (DOCA), and to compare the model stability between a surgical group (unilateral nephrectomy combined with DOCA injection) and a non-surgical group (DOCA injection alone). Method: Healthy Wistar rats were randomly divided into a surgical group and a non-surgical group according to body weight. Rats in the surgical group underwent left nephrectomy followed by subcutaneous injection of DOCA (50 mg/kg), five times per week for five weeks. Rats in the non-surgical group received DOCA injections following the same protocol for seven weeks without nephrectomy. Both groups were given free access to 1% saline solution throughout the experiment. Tail artery blood pressure was monitored weekly until week 10. Blood pressure changes and model stability were compared between the groups. Results: Results showed that systolic blood pressure reached the hypertensive threshold by week 5 in the surgical group and by week 7 in the non-surgical group. By week 10, both groups maintained elevated blood pressure levels, indicating good model stability. Conclusion: These findings suggest that subcutaneous DOCA administration can effectively induce hypertension in rats without the need for nephrectomy. Compared with the conventional surgical model, the non-surgical method is simpler, safer, reproducible, and has broad applicability for hypertension research.