Parkinson's disease is a common neurodegenerative disease characterized by progressive degeneration of nigrostriatal dopaminergic neurons and Lewy body morphology, the pathogenic mechanism is not yet fully understood, and with the rise in the number of patients, it places a huge burden on patients and society.. Acupuncture, a distinctive therapy in traditional Chinese medicine, has been widely used in the treatment of PD patients to improve motor and non-motor symptoms, and its mechanism may be closely related to the regulation of Programmed cell death-related signaling pathways. This article reviews the role of PCD in PD. PCD including apoptosis, necrotic apoptosis, cellular pyroptosis, iron death, and other forms, plays a key role in the process of neuronal damage in PD. Combined with the research progress of acupuncture intervention for PCD, it provides new ideas for clarifying the scientific connotation of acupuncture treatment for PD and developing new treatment strategies.