Sjogren"s Syndrome (SS) is a chronic autoimmune disease, which usually occurs due to immune system disorders. However, the specific mechanism is still unclear and it cannot be cured. T lymphocytes are an important type of immune cells in the human body, and their role in the occurrence and development of SS has been widely described. They are an important target for anti-SS treatment. Although modern medical treatment of SS can alleviate symptoms and delay progression to some extent, it has obvious clinical limitations and the overall treatment effect is not satisfactory. It is particularly important to find an effective and safe treatment method. Traditional Chinese medicine treats diseases based on the fundamental principles of syndrome differentiation and holistic concept, and has multi-pathway, multi-level, and multi-target anti-SS effects. Studies have found that active ingredients of traditional Chinese medicine such as Fangji Noling Alkaloid, Bai Shao Total Glycosides, and Rhodiola Rhodiola Glycosides, as well as traditional Chinese medicine compound prescriptions such as Runzhuang Lingfang, Yangyin Yijieli Huoxue Fang, and Jiefu Huaxue Shengjing Fang, can regulate the changes of different T lymphocyte subsets by regulating signaling pathways such as PI3K/AKT/mTOR, STAT3, and NF-κB, and synergistically alleviate inflammatory responses, reduce immune infiltration, and improve glandular function, etc., to achieve the therapeutic effect of SS. This article reviews and analyzes the relevant research on traditional Chinese medicine against SS in recent years, and discusses the mechanism of traditional Chinese medicine regulating T lymphocytes against SS. The aim is to provide new ideas for the clinical treatment of SS.