基于数据挖掘的糖尿病心肌病动物模型应用分析
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河南中医药大学第一附属医院心脏中心

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国家自然科学(No:82074226);河南省中医药科学研究专项 (No:2024ZY2013,No:2023ZXZX1165);河南省高校科技创新团队支持计划:心血管疾病中医慢病防控研究(25IRTSTHN033)


Application Analysis of?Diabetic Cardiomyopathy Animal Models Based on Data Mining
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Heart Center, The First Affiliated Hospital of Henan University of Chinese Medicine

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    摘要:

    目的 通过统计分析国内外在构建糖尿病心肌病(Diabetic cardiomyopathy,DCM)动物模型时所涉及的关键造模要素及检测指标,以建立能够真实反映糖尿病心肌病发病机制的动物模型,为提高造模成功率和为糖尿病心肌病动物模型建立标准提供有价值的参考。方法 在中国知网、万方、维普、PubMed、Web of science数据库中检索近10年有关糖尿病心肌病动物实验的期刊文献,整理归纳实验动物种类、性别、年龄、体重、造模方式、阳性对照药种类及周期、检测指标、发文量和发文质量等,建立数据库并运用Excel 2021、Origin 2022、SPSS Modeler 18.0、Cytoscape 3.10.3进行统计分析。结果 共纳入228篇文献。多采用高糖高脂饮食联合链脲佐菌素诱导雄性SD大鼠制备糖尿病心肌病动物模型;一般通过血糖和超声心动图检查模型复制是否成功; 使用的高频检测手段是Western blotting蛋白免疫印迹法和HE染色;在含有阳性对照药的研究中,应用最多的是二甲双胍,其次是罗格列酮。结论 目前糖尿病心肌病动物模型仍缺乏系统的中医证候评价,造模方式和成模标准暂未统一,未来糖尿病心肌病动物模型造模方法和评价体系还有待进一步完善。

    Abstract:

    Objective To establish an animal model that can truly reflect the pathogenesis of diabetic cardiomyopathy by statistically analyzing the key modeling elements and detection indexes involved in constructing animal models of diabetic cardiomyopathy (DCM) both at home and abroad in order to provide valuable references to improve the success rate of modeling and establish the standard of animal models of diabetic cardiomyopathy. Methods? We searched the journals about diabetic cardiomyopathy animal experiments in China Knowledge, Wanfang, Wipro, PubMed, and Web of Science databases in the past 10 years and organized and summarized the experimental animal species, gender, age, weight, modeling method, positive control drug type and cycle, detection indexes, quantity of articles and the, quality of articles, etc., established a database and used Excel 2021, Origin 2022, SPSS Modeler 18.0, Cytoscape 3.10.3 for statistical analysis.Results? A total of 228 papers were included. Most of the animal models of diabetic cardiomyopathy were prepared in male SD rats induced by a high-sugar and high-fat diet combined with streptozotocin; the success of model replication was generally checked by blood glucose and echocardiography; the high-frequency tests used were Western blotting protein immunoblotting and HE staining; in the studies containing positive control drugs, the most frequently applied drug was metformin, followed by rosiglitazone. Conclusion? At present, the animal model of diabetic cardiomyopathy still lacks a systematic evaluation of Chinese medicine evidence, and the modeling method and the standard of modeling have not been unified, so the modeling method and evaluation system of the animal model of diabetic cardiomyopathy in the future need to be further improved.

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  • 收稿日期:2025-09-19
  • 最后修改日期:2025-11-22
  • 录用日期:2026-05-07
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