Ferroptosis is an iron-dependent form of programmed cell death and plays a key role in the pathological process of lumbar disc degeneration (IVDD). Traditional Chinese medicine, with its advantages in overall conditioning, has demonstrated unique potential in the prevention and treatment of IVDD. This article starts from the pathological mechanism of IVDD and its interaction with ferroptosis, revealing that ferroptosis is not only a pathological driving factor but also a therapeutic regulatory target.. The theory of ferroptosis has great potential in guiding the intervention of IVDD with traditional Chinese medicine. By targeting the key pathways of ferroptosis and exploring the potential mechanisms of ferroptosis-related genes, it provides a new perspective and theoretical basis for the prevention and treatment of IVDD with traditional Chinese medicine, and also lays the foundation for the development of precise treatment strategies.