Alzheimer's disease(AD) is a neurodegenerative disorder characterized primarily by cognitive impairment and executive function deficits. As a crucial innate immune pathway, the abnormal activation of the cyclic GMP-AMP synthase-stimulator of interferon gene(cGAS-STING) signaling pathway in AD has drawn significant attention. This paper discusses the involvement of the cGAS-STING signalling pathway in Alzheimer's disease (AD) through mechanisms including Aβ deposition and abnormal Tau protein aggregation, oxidative stress and mitochondrial dysfunction, neuroinflammation and glial cell abnormalities, synaptic dysfunction, vascular dysfunction, gut microbiota dysbiosis, and autophagy dysfunction, as well as relevant research on intervening in the cGAS-STING signalling pathway for the treatment of AD.The aim is to reveal that the abnormal activation of the cGAS-STING signaling pathway is a significant cause of AD pathogenesis and may serve as a potential intervention target for the treatment of AD.