Myasthenia gravis is a refractory neurological disease with acquired neuromuscular transmission disorders, which is mainly characterized by skeletal muscle weakness and easy fatigue, and the incidence of which has been on the rise year by year, and is particularly pronounced in the elderly population. Conventional Western medical treatment can improve and reduce the clinical symptoms of most patients, but there are problems such as large adverse reactions, high recurrence rate, and difficulties in reducing or stopping the dosage. Therefore, finding a safer and more effective treatment program is a real problem that needs to be solved urgently, and Chinese medicine has a long history of treating myasthenia gravis with remarkable efficacy. Myasthenia gravis belongs to the category of“flaccidity syndrome”in traditional Chinese medicine, and the disease mechanism is mainly related to the deficiency of spleen and stomach qi. Buzhong Yiqi Decoction is the basic formula for strengthening the spleen and benefiting the qi, and the clinical treatment is mostly based on it and its analogous formula. Several studies have confirmed that Buzhong Yiqi Decoction has improved the symptoms of myasthenia gravis by regulating the body's immune system, increasing the strength of skeletal muscles, regulating the intestinal flora, and inhibiting inflammation. In recent years, a large number of studies have been carried out on the treatment of myasthenia gravis with tonifying zhong yi qi tang, thus, this article combines the relevant recent research progress, in order to provide scientific basis for the clinical application of this formula and subsequent in-depth research.