基于中西医临床病证特点的宫颈癌动物模型分析
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河南中医药大学 药学院

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]国家自然科学基金委员会面上项目(82274119),河南省重点研发专项(251111310400),河南省中医药科学研究重大专项(2024ZYZD15),河南省重点研发专项计划(241111311500),河南省中医药科学院揭榜挂帅项目(2025ZKY006),河南省中医学“双一流”创建科学研究专项(HSRP-DFCTCM-P-10,HSRP-DFCTCM-202-5-03,HSRP-DFCTCM-2023-5-10,HSRP-DFCTCM-2023-1-14),2020年河南省重大公益专项(201300310100),河南省高等学校重点科研项目计划(25CY021)。


Analysis of Cervical Cancer Animal Models Based on the Clinical Characteristics of Traditional Chinese and Western Medicine
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College of Pharmacy, Henan University of Chinese Medicine

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    摘要:

    宫颈癌发病呈年轻化趋势,严重危害女性生命健康,目前针对该病仍缺乏显著有效的治疗方案。为推进宫颈癌临床诊治的发展,筛选出符合宫颈癌病证特点的动物模型十分重要。通过总结现有宫颈癌动物模型,主要包括自发性宫颈癌、诱发性宫颈癌、移植性宫颈癌以及基因工程性宫颈癌。基于宫颈癌中西医临床病证特点对各模型赋值进行分析,发现宫颈癌移植性动物模型的中西医吻合度相对较高,其中皮下移植法西医临床吻合度达70%且最为常用,宫颈原位移植法中医临床吻合度达68.5%;自发、诱发性模型造模成功率不高,模型间差异大,且吻合度不高,较少使用。总体来看,模型中医吻合度均较低,不利于宫颈癌的中西医结合诊治发展,故又提出施加中医致病因素、中医模型评判标准等建议,以期完善宫颈癌模型发展,推动临床疾病研究。

    Abstract:

    Cervical cancer (CC) exhibits a younger age of onset and severely endangers women"s life and health. Currently, there remains a lack of significantly effective therapeutic regimens for this disease. To promote the development of clinical diagnosis and treatment of cervical cancer, it is crucial to screen animal models that conform to the clinical syndrome characteristics of cervical cancer. By summarizing existing animal models of cervical cancer, they mainly include spontaneous cervical cancer, induced cervical cancer, transplanted cervical cancer, and genetically engineered cervical cancer. Through assignment analysis of each model based on the clinical syndrome characteristics of cervical cancer in traditional Chinese and Western medicine (TCM-WM), it was found that the transplanted animal models of cervical cancer have a relatively high degree of TCM-WM consistency. Among them, the subcutaneous transplantation method has a Western medicine clinical consistency of 70% and is the most commonly used, while the orthotopic cervical transplantation method has a TCM clinical consistency of 68.5%. Spontaneous and induced models are less frequently used due to low modeling success rates, significant inter-model differences, and poor consistency. Overall, the TCM consistency of all models is relatively low, which is not conducive to the development of integrated TCM-WM diagnosis and treatment of cervical cancer. Therefore, suggestions such as applying TCM pathogenic factors and establishing TCM model evaluation criteria are proposed to improve the development of cervical cancer models and promote clinical disease research.

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  • 收稿日期:2025-11-07
  • 最后修改日期:2025-12-30
  • 录用日期:2026-05-27
  • 在线发布日期: 2026-07-07
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