The PTEN-induced putative kinase 1/E3 ubiquitin ligase (PINK1/Parkin) signaling pathway plays a critical role in maintaining mitochondrial quality homeostasis by regulating mitophagy. Dysfunction of this pathway is closely associated with the pathogenesis, progression, and potential therapeutic strategies of Alzheimer's disease (AD). This review summarizes recent advances in understanding the mechanisms of the PINK1/Parkin pathway in AD, as well as the progress in modulating this pathway through Traditional Chinese Medicine (TCM) compounds and their active ingredients.Studies indicate that impaired PINK1/Parkin signaling leads to the accumulation of damaged mitochondria, thereby exacerbating β-amyloid (Aβ) plaque deposition, Tau protein hyperphosphorylation, neuroinflammation, and oxidative stress. This creates a vicious pathological cycle that drives the progression of AD. In terms of therapeutic intervention, TCM can dynamically and bidirectionally modulate the PINK1/Parkin pathway: on one hand, activating it to promote the clearance of damaged mitochondria and improve mitochondrial function; on the other hand, inhibiting its overactivation to maintain autophagic homeostasis and prevent excessive neuronal death. Furthermore, TCM can alleviate oxidative stress, suppress neuroinflammation, intervene in Aβ and Tau pathologies, and activate upstream regulators such as SIRT1/3-FOXO3 and AMPK, thereby forming a multi-target, holistic regulatory network.This review provides an important reference for a deeper understanding of the pathological mechanisms of AD and for exploring TCM-based therapeutic strategies targeting the PINK1/Parkin pathway.