基于“治水者必先治气”探讨桂枝活性成分治疗痛风性肾病的研究进展
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河南中医药大学第一附属医院

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河南省中医药传承与创新人才工程(仲景工程)中医药学科拔尖人才(CZ0237-15);河南省中医药科学研究专项课题(2024ZXZX1052);河南省卫生健康委员会基地专项课题(2021JDZY083);国家中医临床研究基地专项(2022JDZX078);重点学科建设-中医痹病学(15102040X-5-14)


Research Progress on the Treatment of Gouty Nephropathy with Active Components of Cinnamomi Ramulus Based on the Theory of "Treating Water Must First Treat Qi"
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河南中医药大学第一附属医院

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    摘要:

    痛风性肾病是高尿酸血症最常见的微血管并发症,也是导致慢性肾脏病进展至终末期肾病的独立危险因素,其高致残率与高医疗负担已成为全球公共卫生难题。当前西医治疗以降尿酸、抗炎为核心,但长期使用相关药物易引发肝损伤、骨髓抑制等不良反应,且难以阻断尿酸盐结晶介导的肾间质纤维化进程。中医药在慢性病防治中具有“整体调控、多靶点干预”的独特优势,基于张景岳提出“治水者必先治气”的核心理论,文章聚焦“温通阳气、化气行水”的经典中药桂枝,系统梳理其挥发油类(桂皮醛等)、黄酮类(桂枝苷等)及有机酸类(肉桂酸等)核心活性成分,从调节尿酸代谢平衡、抑制炎症级联反应、改善氧化应激、抗肾细胞死亡、延缓肾纤维化及调控“肠-肾轴”功能等维度,总结其干预痛风性肾病的核心作用机制,也为中医药干预痛风性肾病的新药研发与临床用药提供新思路。

    Abstract:

    Gouty nephropathy is the most common microvascular complication of hyperuricemia and also an independent risk factor for the progression of chronic kidney disease to end-stage renal disease. Its high disability rate and heavy medical burden have become a global public health challenge. At present, western medicine treatment is centered on uric acid lowering and anti-inflammation, but long-term use of these medications may lead to adverse effects such as liver injury and bone marrow suppression, and it is difficult to block the process of renal interstitial fibrosis mediated by urate crystals. Traditional Chinese medicine (TCM) possesses unique advantages of "holistic regulation and multi-target intervention" in the prevention and treatment of chronic diseases. Based on the core theory of "Treating water must first treat qi" proposed by Zhang Jingyue, this article focuses on Cinnamomi Ramulus, a classic TCM herb with the effects of "warming and unblocking yang-qi, promoting qi movement to induce diuresis". It systematically sorts out its core active components, including volatile oils (such as cinnaldehydum), flavonoids (such as Cinnamomi glycoside), and organic acids (such as cinnamic acid). From the perspectives of regulating the balance of uric acid metabolism, inhibiting inflammatory cascade reactions, improving oxidative stress, resisting renal cell death, delaying renal fibrosis, and regulating the function of the "gut-kidney axis", this article summarizes the core mechanisms of its intervention in gouty nephropathy, and also offers new ideas for the research and development of new TCM drugs and clinical medication for TCM intervention in gouty nephropathy.

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  • 收稿日期:2025-12-11
  • 最后修改日期:2026-02-12
  • 录用日期:2026-03-13
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