Xenotransplantation offers a new solution to the crisis of organ shortage. Genetically edited pigs have become a key source of donor animals. However, this technology has transformed the role of donor animals from traditional experimental subjects to "living organ bioreactors", raising multiple ethical challenges across species, genetic intervention, and public health, marking a shift in the ethical review of laboratory animals from management of usage to governance at the source. This article, based on the dual perspectives of laboratory animal science and ethical review, systematically analyzes the core dimensions of ethical review for xenotransplantation donor pigs, including animal status, risk attributes, technical uncertainty, and ethical conflicts. By reviewing the ethical review concepts and practices regarding cross-species transplantation both domestically and internationally, it reveals the structural dilemmas in the current ethical review in terms of standards, capabilities, and collaborative mechanisms. On this basis, suggestions are put forward for constructing the animal ethical review system for cross-species transplantation in China, with the aim of promoting the ethical review from formal compliance to substantive governance, and providing ethical support for the healthy development of cross-species organ transplantation in China.