| 蔡晓雯,赖惠芹,梁开勇,黄 泳.TAAR1,CNS 单胺神经元调控新靶点[J].中国比较医学杂志,2022,32(4):126~132. |
| TAAR1,CNS 单胺神经元调控新靶点 |
| Trace amine-associated receptor 1 is a new regulating target of monoamine neurons in the central nervous system |
| 投稿时间：2021-06-10 |
| DOI：10. 3969 / j.issn.1671-7856. 2022. 04. 018 |
| 中文关键词: 痕量胺相关受体 1 痕量胺 单胺类神经递质 中枢神经系统 |
| 英文关键词:trace amine-associated receptor 1 trace amines monoamine neurotransmitter central nervous system |
| 基金项目: |
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| Author Name | Affiliation | E-mail | | CAI Xiaowen | School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China | cxw0922@ 126.com | | LAI Huiqin | Department of Oncology, Zhongshan Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Zhongshan 528400 | lhq2646592073@ 163.com | | LIANG Kaiyong | School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China | | | HUANG Yong | 1. School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China. 2. Department of Acupuncture, Nanfang Hospital, Guangzhou 510515. | nanfanglihuang@ 163.com |
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| 中文摘要: |
| 痕量胺相关受体 1(TAAR1)是神经精神疾病研究的新信号,在中枢神经系统(CNS)功能中具有重要的生理作用。 研究发现,TAAR1 的作用发挥除了跟传统配体痕量胺有关,还与单胺类神经递质有密切关联。 本文从 TAAR1 的表达、相关配体、作用机制通路和与单胺类神经递质的关系几个方面,介绍了 TAAR1 在 CNS 中通过多巴胺能、5-羟色胺能、谷氨酸能神经元,从而影响细胞内外相关物质水平来调节中枢神经系统功能,且其激动剂在药理实验中也表现出巨大潜能。 TAAR1 的研究在神经精神类疾病上展现的优势越来越明显,具有较好的研究前景。 |
| 英文摘要: |
| Trace amine-associated receptor 1 (TAAR1) is a new signal in neuropsychiatric research and plays an important physiological role in the central nervous system. Various reports have shown that the role of TAAR1 is closely related to trace amines and monoamine neurotransmitters. We discuss the research on TAAR1 in recent years from the aspects of TAAR1 expression, related ligands, mechanism pathway and the relationship with monoamine neurotransmitters. TAAR1 regulates dopaminergic, serotoninergic and glutamatergic neurons in the central nervous system and thus affects the levels of related substances inside and outside the cell. TAAR1 agonists also show great potential for promoting the cognitive function in pharmacological experiments. Targeting this receptor shows increasing advantages and potential for use in neuropsychiatric diseases. |
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