Objective To study the content of 8 mineral elements in the heart,liver and lungs of SPF BALB/c nude mice.Methods The contents of Zn,Cu,Fe,Ca,Mg,Mn,P,S in the heart,liver and lungs of BALB/c nude mice homozygotes(nu/nu)were determined by inductively coupled plasma-atomic emission spectrometry (ICP-AES).Results There were significant differences in the contents of Zn,Mg,Mn,P,S in the heart,liver and lung between male and female BALB/c nude mice.There were also significant differences in the contents of Zn,Cu,Ca,Mg,Mn,P, S in the three organs.The sequence of mineral element content in the heart,liver and lungs in male and female BALB/c nude mice was uniform.Conclusion The distribution of mineral elements in the heart,liver and lungs of BALB/c nude mice shows some regularities.The contents of some elements in the heart,liver and lungs of BALB/c nude mice are to certain extent affected by gender.