Along with the rise of the research of neurpeptide in neurobiology field,Peptidic neurotransm itters-somatostain becomes the hot spot of researching the pathogenesis of depression.In this article we comprehensively summarize the documents of the structure and distribution of somatostain,the type and distribution of somatostain receptor,the effect of somatostain,the change of somatostain content and,the pathogenesis in depression and the adjusting function of TCM on the animal model's somatostain.