Objective To investigate the effects of ERK on asthma airway remodeling and the expressions of cyclinD1.Methods The rat asthma model was made through ovalbumin(OVA) sensitization and excitation.Primary cultures of ASMCs were established and cells between passages 3 and 6 were used for experiments.ASMCs were treated with ERK activator epidermal growth factor(EGF) and inhibitor PD98059,and then subdivided into 5 groups based on the drug interventions:(1)Normal control group;(3)Asthmatic control group;(3)Asthm...