Objective To study the role of RunX3 gene in the self-renewal and differentiation of hematopoietic stem cells(HSC) .Methods The number and function of hematopoietic stem cells in RunX3 knockout mice were determined by competitive bone marrow transplantation and flow cytometry.Results The number of bone marrow stem cells in RunX3 knockout mouse was the same as those of wild type control mice.Competitive transplantation revealed no difference of HSC self-renewal in RunX3 knockout mouse,but a putative differen...