Objective To analyze the therapeutic effects of 12 herbal monomers on APPswe /PS1 ΔE9 transgenic mice，and to explore promising candidates for treatment of Alzheimer disease. Methods APPswe /PS1 ΔE9 transgenic mice at age of 5 months were randomized into 14 groups. One group was vehicle group ( placibo) and one group was Aricept group as positive control. The other 12 groups were used for treatment with the 12 herbal monomers，respectively. The littermates of no-negative mice were used as normal control. Morris water-maze test was performed at 4 weeks after treatment to assess the nervous function. Results The evodiamine-treated mice showed significantly decurtated latency and increased number of crossings of the removed-platform area in Morris water maze test，compared with that of the vehicle group. Conclusions Evodiamine treatment can improve the learning and memory ability in APPswe /PS1 ΔE9 double-transgenic mice.