Objective To obtain the basic data of biological parameters of F1 of a self-established C57-ras transgenic mice． Methods The blood samples were collected and tested for physiological values using MEK 27222K hematology analyzer and biochemical values using Olympus AU400 auto 2 analyzer． The weight of organs and bodies were determined with electronic balance and the data were analyzed statistically． Results The MCHC of F1 female transgenic mice and non-transgenic mice had extremely significant difference ( P ＜ 0. 01 ) . The PLT，PCT，EOS% ，NEUT， NEUT% ，LYM% of CB6F1-Tg male mice and non-transgenic mice had significant difference ( P ＜ 0. 05 ) ，and that of NEUT% ，LYM% had extremely significant difference (P ＜ 0. 01) ． Among the sera biochemical data，ALT，TP，ALB had significant difference ( P ＜ 0. 05 ) ． The statistical analyzing results of organ weight and coefficient show that had no extremely significant difference (P ＞ 0. 05) ． TG had extremely significant difference (P ＜ 0. 01) ． Conclusions The F1 of new-established mouse model has been obtained the biological characters with the normal C57BL /6 mice; this may be favorable for its usage in the pre-clinical safety evaluation．