Objective To explore the effect of leptin and transforming growth β1 in fibrosis liver． Methods The female Wistar rats were randomly divided into normal control group and four model groups( 1 week ，2 week ，4 week ，6week) ． Carboan tetrachloride was injected for establishing hepatic fibrosis model in model groups． The levels of leptin and transforming growth β1 were determined ． The pathological hepatic changes were observed by HE． The degree of liver fibrosis was observed by stained of sirius red of collagen and the content of hydroxyproline in liver tissues，and the relationship with leptin and transforming growth β1 and FI were amalyzed． The ALT of serum was mensurated with laishi method． Results Compared with control group，the expression of leptin and transforming growth β1 increased significantly in liver fibrosis group ( P ＜ 0. 05 ) ． The expression of leptin and transforming growth β1 in liver tissue were correlated positively with FI in liver fibrosis group． Conclusions The results of the study demonstrate increased leptin and transforming growth β1 levels of liver tissue in liver fibrosis model groups，and activating leptin may up-regulate the expression of transforming growth β1 during experimental hepatic fibrosis．