Objective To discuss the effect of cyclosporinA on acellular heterogeneous nerve transplant in Wistar rats． Methods 48 Wistar rats' each side were randomly expeimental side． After facial nerve were unveiled，1 cm defect were produced． All the animals were divided into 4 groups by kinds of graft nerve． Group A: heterogeneous nerve transplant; Group B: heterogeneous nerve transplant with CSA; Group C: acelluler heterogeneous nerve transplant; Group D: acelluler heterogeneous nerve transplant with CSA． 5 and 12 weeks after operation，we carried through the electrophysiology ( latent period，motor nerve conduction speed) and observed the morphological under light and trasmission electronic microscope． Results 5 weeks after operaton，the generation facial nerve of each group were incomplete and the function did not resume． 12 weeks after operaton，the parameters of group C and D were better than group A and B． There were significant difference between group D and other groups on conduction velocity． Conclusion In the experiment of 1 cm facial nerve defect，the CSA can reduce immunoreaction and increase the facial regenarion．