A Proved Neurological Deficit Scale of Non-human Primate
CSTR:
Author:
Affiliation:

1. Key Laboratory of Human Diseases Comparative Medicine,Ministry of Health; Institute of Medical Laboratory Animal Science,Chinese Academy of Medical Sciences; Key Laboratory of Human Diseases Animal Models,State Administration of Traditional Chinese Medicine; Beijing Union Medicine College,Beijing 100021,China;2. Motac Laboratory,Institute of Laboratory Animal Science,Chinese Academy of Medical Sciences,Beijing 100021,China; 3. Peking Union Medical College Hospital,Beijing 100730,China;4. Institute of Basic Medical Science,PUMC & CAMS,Beijing 100005,China;5. Beijing Institute of Neurological Surgery,Beijing 100050,China.

Clc Number:

Fund Project:

  • Article
  • |
  • Figures
  • |
  • Metrics
  • |
  • Reference
  • |
  • Related
  • |
  • Cited by
  • |
  • Materials
  • |
  • Comments
    Abstract:

    Objective Use the proved Non-human Primate Neurological deficit scale to evaluate the effect of Intracerebral Hemorrhage model of Cynomolgus macaques Treatment with Human Bone Marrow Mesenehymal Stem Cells. Methods 12 adult male Cynomolgus monkeys were used in this study. The Intracerebral Hemorrhage model were made by using the autologous anticoagulated femoral artery blood injection. 12 monkeys were divided into three groups one week after the surgery. The control group consisted of four animals receiving physiological saline in the volume of 250μl 3 mm away from the outside edge of the infarcts. The high-dose and low-dose group receiving Human Mesenchymal Stem Cell( hMSC) with the cell number of 5 × 106 and 1 × 106 at the same place and volume with the control group. Use the Non-human Primate Neurological deficit scale and / or proved to evaluate the effect of the stem cell at the 6h,1d,3d,1week after surgery and 1,3 day and 1,2,3,4 weeks after transplantation. Result Compared with the group,the score of the dose-group animals much slower than that in the control group after transplantation ( p < 0. 05) . There is no significant difference between high-dose and low-dose group. Conclusion The proved Non-human Primate neurological deficit scale is more objectively and accurately than the original one and can be used to measure neuronal loss in vivo and to evaluate the effects of therapeutic strategies involving neural or stem cell transplantation.

    Reference
    Related
    Cited by
Get Citation
Related Videos

Share
Article Metrics
  • Abstract:
  • PDF:
  • HTML:
  • Cited by:
History
  • Received:May 10,2011
  • Revised:
  • Adopted:
  • Online: December 16,2025
  • Published:
Article QR Code