Mouse is the most popular laboratory animal in medical research． As an animal model，mouse has been used for human cancer research for over one century，a large number of genetic variations in mice can be used as reference for the study of human cancer． Over the past 20 years，genetically engineered mouse( GEM) ，including transgenic mouse，knock-out mouse，have been cultured，thus，paved a way to deepen our understanding of cancer diagnosis，innovative therapeutic，and prevention． In this review paper，we mainly introduce spontaneous and inducible cancer mouse models and GEM models． In addition，some recent strategies and accomplishments for producing complicated cancer models in the mouse as well as the limitation of mouse model are discussed．