Results of quality control test and even the quality of the products are directly affected by SPF chickens and SPF embryos ，which are the main raw materials of production and quality inspection in veterinary biological products．Chickens and embryos must meet the national SPF animal standards requirement from the animal standards in production and inspection in the veterinary pharmacopoeia of the People's Republic of China ( 2010 ) ，in the seed lots and biological products preparation and quality inspection． The quality control of SPF chicken includes four tests，namely inheritance，microorganism ，environment and nutrition respectively． The current standards for quality control of SPF chickens are reviewed in the perspective of bioproducts enterprises． In this article，critical ideas and practical proposals for quality control of SPF chickens based on the practice of production and quality inspect in poultry live vaccine are presented．