ObjectiveTo investigate prevention and cure effect of Ulinastatin(UTI) combined with XUEBIJING(XBJ) on multiple organ dysfunction syndrome(MODS) induced by lip polysaccharide (LPS) in sheep . Methods50 sheep were randomly separated into 5 groups :the control(Group A), model group (Group B), UTI group (Group C), XBJ group(Group D) and UTI + XBJ group (Group E), 10 sheep each group . The MODS model was established by LPS in sheep. It was prevented and cured by UTI, XBJ and UTI + XBJ. Then the physical sign appearance was observed and the indexes of blood gas, blood routine and blood biochemistry were determined in each group. ResultsThe sheep in UTI＋XBJ group, the physical sign appearance was obviously alleviative, the death rate was markedly degraded. Arterial oxygen pressure (PaO₂), the biochemical indexes and the number of WBC was regulated efficiently. ConclusionUTI + XBJ could improve obviously physical sign appearance, degrade the death rate and it had favourable preventive and therapeutic effect on damage in multiple organ. 