+Advanced Search
Home > Archive>Volume , Issue 3, 2012 >40-44. DOI:10.3969/j.issn.1671.7856.2012.003.009
PDF HTML XML Export Cite reminder
Regulation of Branching Morphogenesis in Kidney Development
Author:
  • Article
    • | |
  • Metrics
    • |
  • Reference [30]
    • | | | |
  • Comments
    Abstract:

    Development of the kidney is initiated when the caudal region of the Wolffian duct (WD) swells and then buds out into the adjacent metanephric mesenchyme (MM) induced by GDNF. Then FGF, HGF, BMP, MMP, integrin and adhesion molecules are expressed in the UB and MM result in branching morphogenesis, including the ureteric bud (UB) invation into the MM, the elongation of the UB and mesenchymal-epithelial transition (MET). Those molecules function in maintaining a balance of cell proliferation and differentiation to ensure normal formation of the branches. Also, there are parts of overlap and antagonist between those growth factors. This review focuses on the regulation of branching morphogenesis.

    Reference
    [1] Costantini F.Renal branching morphogenesis:concepts, questions, and recent advances[J].Differentiation, 6,4(7):402-421.
    [2] Skinner M A, Safford S D, Reeves J G, et al.Renal aplasia in humans is associated with RET mutations[J].Am J Hum Genet, 8,2(2):344-351.
    [3] Chi X, Michos O, Shakya R, et al.Ret-dependent cell rearrangements in the Wolffian duct epithelium initiate ureteric bud morphogenesis[J].Dev Cell, 9,7(2):199-209.
    [4] Majumdar A, Vainio S, Kispert A, et al.Wnt11 and Ret/Gdnf pathways cooperate in regulating ureteric branching during metanephric kidney development[J].Development, 3,0(14):3175-3185.
    [5] Michos O, Cebrian C, Hyink D, et al.Kidney development in the absence of Gdnf and Spry1 requires Fgf10[J].PLoS Genet, 0,6(1):e1000809.
    [6] Tufro A, Teichman J, Woda C, et al.Semaphorin3a inhibits ureteric bud branching morphogenesis[J].Mech Dev, 8,5(5-6):558-568.
    [7] Lu B C, Cebrian C, Chi X, et al.Etv4 and Etv5 are required downstream of GDNF and Ret for kidney branching morphogenesis[J].Nat Genet, 9,1(12):1295-1302.
    [8] Satu Kuure X C.The transcription factors Etv4 and Etv5 mediate formation of the ureteric bud tip domain during kidney development[J].Development, 0,7:1975-1979.
    [9] Grieshammer U, Cebrian C, Ilagan R, et al.FGF8 is required for cell survival at distinct stages of nephrogenesis and for regulation of gene expression in nascent nephrons[J].Development, 5,2(17):3847-3857.
    [10] Zhuang L, Villiger P, Trueb B.Interaction of the receptor FGFRL1 with the negative regulator Spred1[J].Cell Signal, 1,3(9):1496-1504.
    [11] Bottaro D P, Rubin J S, Faletto D L, et al.Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product[J].Science, 1,1(4995):802-804.
    [12] Vargas G A, Hoeflich A, Jehle P M.Hepatocyte growth factor in renal failure:promise and reality[J].Kidney Int, 0,7(4):1426-1436.
    [13] Liu Z, Greco A J, Hellman N E, et al.Intracellular signaling via ERK/MAPK completes the pathway for tubulogenic fibronectin in MDCK cells[J].Biochem Biophys Res Commun, 7,3(3):793-798.
    [14] Togawa A, Sfakianos J, Ishibe S, et al.Hepatocyte Growth Factor stimulated cell scattering requires ERK and Cdc42-dependent tight junction disassembly[J].Biochem Biophys Res Commun, 0,0(2):271-217.
    [15] Dudley A T, Lyons K M, Robertson E J.A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye[J].Genes Dev, 5,9(22):2795-2807.
    [16] Cain J E, Bertram J F.Ureteric branching morphogenesis in BMP4 heterozygous mutant mice[J].J Anat, 6,9(6):745-755.
    [17] Cain J E, Nion T, Jeulin D, et al.Exogenous BMP-4 amplifies asymmetric ureteric branching in the developing mouse kidney in vitro[J].Kidney Int, 5,7(2):420-431.
    [18] Davies J.Intracellular and extracellular regulation of ureteric bud morphogenesis[J].J Anat, 1,8(Pt 3):257-264.
    [19] Hogan B L.Bone morphogenetic proteins:multifunctional regulators of vertebrate development[J].Genes Dev, 6,0(13):1580-1594.
    [20] Goncalves A, Zeller R.Genetic analysis reveals an unexpected role of BMP7 in initiation of ureteric bud outgrowth in mouse embryos[J].PLoS One, 1,6(4):e19370.
    [21] Karihaloo A, Nickel C, Cantley L G.Signals which build a tubule[J].Nephron Exp Nephrol, 5,0(1):e40-45.
    [22] Onodera T, Sakai T, Hsu JC, et al.Btbd7 regulates epithelial cell dynamics and branching morphogenesis[J].Science, 0,9(5991):562-565.
    [23] Costantini F, Kopan R.Patterning a complex organ:branching morphogenesis and nephron segmentation in kidney development[J].Dev Cell, 0,8(5):698-712.
    [24] Mori H, Gjorevski N, Inman JL, et al.Self-organization of engineered epithelial tubules by differential cellular motility[J].Proc Natl Acad Sci U S A, 9,6(35):14890-14895.
    [25] Zhang X, Mernaugh G, Yang D H, et al.beta1 integrin is necessary for ureteric bud branching morphogenesis and maintenance of collecting duct structural integrity[J].Development, 9,6(19):3357-3366.
    [26] Liu Y, Chattopadhyay N, Qin S, et al.Coordinate integrin and c-Met signaling regulate Wnt gene expression during epithelial morphogenesis[J].Development, 9,6(5):843-853.
    [27] Gumbiner B M.Regulation of cadherin-mediated adhesion in morphogenesis[J].Nat Rev Mol Cell Biol, 5,6(8):622-634.
    [28] Marciano D K, Brakeman P R, Lee C Z, et al.p120 catenin is required for normal renal tubulogenesis and glomerulogenesis[J].Development, 1,8(10):2099-2109.
    [29] Martinez-Rico C, Pincet F, Thiery J P, et al.Integrins stimulate E-cadherin-mediated intercellular adhesion by regulating Src-kinase activation and actomyosin contractility[J].J Cell Sci, 0,3(Pt 5):712-722.
    [30] Uchiyama Y, Sakaguchi M, Terabayashi T, et al.Kif26b, a kinesin family gene, regulates adhesion of the embryonic kidney mesenchyme[J].Proc Natl Acad Sci U S A, 0,7(20):9240-9245.
    Related
    Cited by
    Comments
    Comments
    分享到微博
    Submit
Get Citation

Copy
Share
Article Metrics
  • Abstract:1985
  • PDF: 2610
  • HTML: 0
  • Cited by: 0
History
Article QR Code
You are the first3044228 Visitors
® 2025 All Rights Reserved
Address：5 Panjiayuan Nanli, Chaoyang District, Beijing 100021, China Postcode： Phone：86-10-67779337 E-mail:bjb@cnilas.org
Supported by:Beijing E-Tiller Technology Development Co., Ltd.