ObjectiveTo investigate the safety and efficacy of immediately coronary optical coherence tomography (OCT) examination after stent implantation in the mini pig model. Methods Twenty-two health Chinese mini pigs were given percutaneous coronary stent implantation in right coronary artery. Stent strut malapposition was evaluated by OCT analysis. The duration and complication of OCT examination were recorded at the same time. ResultsOCT examination was performed on 25 stents and failed in 3 cases (1 pig had guiding wire fractured inside stent and 2 had coronary artery spasm and failed to deliver the occlusion balloon). Side effect contained 5 cases of temporarily ST segment elevation and 3 cases of ventricular fibrillation (2 pigs survived after successful electrical defibrillation and 1 dead). The mean duration of operation and OCT examination was 49.7±12.9 minutes and 17.9±4.9 minutes respectively. OCT detected 4514 stent struts and discovered 66 malapposition struts. And the rate of malapposition strut immediately after stent implantation was 1.46%. ConclusionOCT examination could be applied on mini pig stent implantation model with high quality and safety and was effective enough to evaluate the strut malapposition immediately after stent implantation.