Objective To investigate the morbility of MODS in different altitude and observe the change of blood biochemistry by the animal model of multiple orgen dysfunction syndrome (MODS) induced by lipopolysaccharide (LPS) in sheep.Methods 12 sheep were randomly separated into 2 groups, 6 sheep each group:the highland region of Sangke prairie (average altitude 3100 m) , sub highland region of Lanzhou group (average altitude 1520 m). After anaesthetizing , the MODS model was established by infusing 6 μg / kg LPS in 30 minutes intravenously in sheep. Then the physical sign appearance was observed and the indexes of blood biochemistry were determined in each group at different times.ResultsThe sheep in Sangke group, the death rate was markedly raised. The CK、CK-MB、AST、ALT、CRE biochemical indexes was markedly higher compared with Lanzhou group, except ALP that was little change. Conclusion MODS has the more damage in multiple organ follow on the raising altitude at highland.