Objective To analyze blood routine in adjuvant arthritis rats. Methods Complete Freund's adjuvant-induced arthritis models were established in Wistar rats, and detection of blood routine was carried out by the automatic blood analyzer. Results Compared to normal rats, 14 blood test indicators were significantly different in adjuvant-induced arthritis rats. Conclusion The leukocytes count was significantly increased in adjuvant-induced arthritis rats, and anemia of chronic disease similar to people rheumatoid arthritis appeared.