XUE Jin-long
Beijing University of Chemical Technology, College of Materials Science and Engineering, Beijing 100029, ChinaSUN Fang-ling
Department of Pharmacology, Xuanwu Hospital of Capital Medicial University, Beijing 100053, ChinaLUI Ting-ting
Department of Pharmacology, Xuanwu Hospital of Capital Medicial University, Beijing 100053, ChinaHOU Hong-li
Hebei North University, Hebei Zhangjiakou 075000, ChinaWEI Ren-ping
Hebei North University, Hebei Zhangjiakou 075000, ChinaXIANG Ben-xu
Department of Pharmacology, Xuanwu Hospital of Capital Medicial University, Beijing 100053, ChinaAI Hou-xi
Department of Pharmacology, Xuanwu Hospital of Capital Medicial University, Beijing 100053, ChinaWANG Yu-lan
Department of Pharmacology, Xuanwu Hospital of Capital Medicial University, Beijing 100053, ChinaZHANG Li
Department of Pharmacology, Xuanwu Hospital of Capital Medicial University, Beijing 100053, ChinaSHI Shu-xian
Beijing University of Chemical Technology, College of Materials Science and Engineering, Beijing 100029, ChinaWANG Wen
Department of Pharmacology, Xuanwu Hospital of Capital Medicial University, Beijing 100053, ChinaObjective To investigate the effects of morroniside on the expression of Wnt7a and APC in rat cortex of focal cerebral ischemia/reperfusion. Methods After middle cerebral artery occlusion (MCAO) model was performed SD rats were divided into groups of sham, model, and morroniside (30 mg/kg, 90 mg/kg,270 mg/kg). The expression of Wnt7a and APC were evaluated by Western blot. Results Compared with the sham group, the expression of Wnt7a in rats of MCAO model was increased, and the expression of APC was decreased. Compared with model group, morroniside at the concentrations of 30 mg/kg, 90 mg/kg, 270 mg/kg decreased APC expression respectively, while 270 mg/kg morroniside-treatment obviously increased the expression of Wnt7a. Conclusion Morroniside could increase the expression of Wnt7a, and inhibit the expression of APC after ischemic injury, therefore activating the Wnt signaling pathway.
