Objective To study the effects of different hypertonic saline (4.5% and 7.5%) in fluid resuscitation on hemodynamics in traumatic rabbits with hemorrhagic shock. Methods Thirty-two healthy rabbits (male or female, 2.0-3.0 kg body weight) were divided into 4 groups randomly: SHAM group, SWT group (shock without treatment), 4.5% group (resuscitation with 4.5% hypertonic saline), and 7.5% group (resuscitation with 7.5% hypertonic saline), 8 rabbits in each group. The rabbit model of uncontrolled hemorrhagic shock was established after anesthesia. The fluid used in the two methods of fluid resuscitation was infused into the rabbits at designed times. The hemodynamic data including the left intraventricular systolic pressure (LVSP) and maximal change rate of left intraventricular pressure (±dp/dtmax) were determined at 0 min, 30 min, 60 min, and 90 min. Results (1) The rabbit models of uncontrolled hemorrhagic shock were generated successfully. At 30 min, data of SWT in the 4.5% and 7.5% groups had no significant difference through pairwise comparison (P>0.05). (2) The hemodynamic parameters changed similarly during the experiment. At 60 min, the values of the 7.5% group (LVSP=115.00±8.37 mmHg, +dp/dtmax=4.29±0.50 mmHg/ms, -dp/dtmax=-3.25±0.25 mmHg/ms) were significantly higher than those in the 4.5% group ((LVSP=104.14±7.73 mmHg, +dp/dtmax=3.35±0.39 mmHg/ms, -dp/dtmax=-2.27±0.12 mmHg/ms) (P<0.05). At 90 min, the data of the 7.5% group were higher, but statistically not significantly different (P>0.05). Conclusions Fluid resuscitation can improve the hemodynamic function in traumatic rabbits with uncontrolled hemorrhagic shock. Comparing with the 4.5% hypertonic saline, 7.5% hypertonic saline can improve the hemodynamic function more apparently. Our results may provide an experimental support for the treatment of clinical patients with uncontrolled hemorrhagic shock.