Phospholipase A2(PLA2)is a class of enzymes with the ability to catalyze hydrolysis of lipoproteins and glycerophospholipid in the membrane, mainly including secreted PLA2(sPLA2),cytosolic PLA2(cPLA2), Ca²⁺-independent PLA2(iPLA2) and lipoprotein-associated phospholipase A2(Lp-PLA2). They are closely related to many diseases.The studies of the role of PLA2 in cardiovascular diseases have been a hot topic in recent years. This paper focuses on the recent advances in research on the effects of PLA2 on cardiovascular diseases in animal experiments.