Promoting effect of Lycium chinense Mill on hematopoietic reconstruction in mice after radiation injury
Author:
  • Article
  • | |
  • Metrics
  • |
  • Reference [8]
  • | | | |
  • Comments
    Abstract:

    Objective To investigate the effect of Lycium chinense Mill on hematopoietic reconstruction in mice after radiation injury. Method Female C57BL/6J mice were grouped to 3 groups at random: the control group, with normal food and no treatment, and the other 2 groups, treated with 4.5 Gy irradiation, with normal food or food added with Lycium chinense Mill. After 1 month, the mice were sacrificed and analyzed the peripheral blood, spleen, thymus and bone marrow cells by flow cytometer. Results In the mice fed with Lycium chinense Mill, the percentage of B cells was increased in the peripheral blood, the pre-B and immature B cells were increased, too, and the percentage of hematopoietic stem/progenitor cells was decreased. Conclusion Lycium chinense Mill can promote the mobilization and differentiation of hematopoietic stem/progenitor cells, and accelerate the hematopoietic reconstruction after irradiation injury.

    Reference
    [1] 罗琼, 闫俊, 李瑾玮, 等. 纯品枸杞多糖对小鼠免疫功能的影响 [J]. 中国老年学杂志, 1999, 19(1): 38-41.
    [2] 闫秀英, 许志华, 韩丽莎, 等. 枸杞子对四氯化碳致大鼠肝脂类过氧化作用的抑制 [J]. 包头医学院学报, 1998, 14(1): 7-9.
    [3] 李明, 张凤英. 枸杞子对成年大白鼠血超氧化物歧化酶活性影响的研究 [J]. 宁夏医学院学报, 1993, 15(1): 67.
    [4] 石瑞如, 刘艳红,赵胜利,等. 人参、枸杞子对老年大鼠心肌β受体的影响 [J]. 中草药, 1998, 29(6): 389-390.
    [5] Chen J, Astle CM, Harrison DE. Genetic regulation of primitive hematopoietic stem cell senescence [J]. Expe Hematol, 2000, 28: 442-450.
    [6] Mandal PK, Blanpain C, Rossi DJ. DNA damage response in adult stem cells: pathways and consequences [J]. Nat Rev Mol Cell Biol, 2011, 12: 198-202.
    [7] Pietras EM, Warr MR, Passegue E. Cell cycle regulation in hematopoietic stem cells [J]. J Cell Biol, 2011, 195:709-720.
    [8] 霍超, 徐桂花. 枸杞生理功效和活性成分的研究进展 [J]. 中国食物与营养, 2007, 13(11):50-53.
    Related
    Cited by
    Comments
    Comments
    分享到微博
    Submit
Get Citation
Share
Article Metrics
  • Abstract:2100
  • PDF: 1799
  • HTML: 0
  • Cited by: 0
History
  • Revised:November 04,2014
  • Online: March 04,2015
Article QR Code