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Home > Archive>Volume 25, Issue 6, 2015 >42-45. DOI:10.3969.j.issn.1671.7856. 2015.006.009
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MDSCs are upregulated in PSGL-1-deficient mice
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    Abstract:

    Objective PSGL-1 is specifically expressed in leucocytes. The aim of this study was to explore the changes of myeloid-derived suppressor cells (MDSCs) in the spleen and bone marrow in PSGL-1-deficient mice. Methods PSGL-1-/- mice were used in the experiment. After identification of the offsprings, flow cytometry was used to test the expression of CD11b and Gr-1 in C57 and PSGL-1-/- mice. Results Compared with the C57 mice, the expression of MDSCs was up-regulated in the PSGL-1-deficient mice (P<0.001). Conclusion The expression of MDSCs is upregulated in PSGl-1-deficient mice.

    Reference
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  • Revised:May 04,2014
  • Online: June 30,2015
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